Can Genetics Explain Why Some Heavy Drinkers Avoid Liver Disease?
Quick Answer Yes, genetics explains a meaningful part of this puzzle. Research consistently shows that only about one in three heavy, long-term drinkers ever develops advanced liver disease. Twin studies confirm this pattern isn’t random chance either. Instead, specific genes — especially HSD17B13 and PNPLA3 — directly shape how a person’s liver responds to years of alcohol exposure. That said, genetics…